This should be particularly taken into account for those on a low salt diet. To email a medicine you must sign up and log in. The most important part is that India is the manufacturing hub of generic medicines and India alone accounts for 90% of the total exports all over the world. Excipients with known effect: Each vial contains 208 mg sodium carbonate approximately 4.0 mmol of sodium (approximately 90 mg).. Each ml of reconstituted solution contains 50 mg Meropenem. Ceftriaxone & Sulbactam for Injection. This is because Meropenem can affect the way some medicines work and some medicines can have an effect on Meropenem. The most commonly reported meropenem-related laboratory adverse events were thrombocytosis (1.6 %) and increased hepatic enzymes (1.5-4.3 %). Hepatic function should be closely monitored during treatment with meropenem due to the risk of hepatic toxicity (hepatic dysfunction with cholestasis and cytolysis) (see section 4.8). In vitro meropenem shows reduced susceptibility to hydrolysis by human dehydropeptidase-I (DHP-I) compared to imipenem and there is no requirement to co-administer a DHP-I inhibitor. Always use Meropenem exactly as your doctor has told you. There was no evidence of increased sensitivity to meropenem in juveniles compared to adult animals. There is no target-based cross-resistance between meropenem and agents of the quinolone, aminoglycoside, macrolide and tetracycline classes. SCHEDULE: SCHEDULE 'H1' DRUG; It is dangerous to take this preparation except in accordance with the medical advice. The dose depends on the type of infection that you have, where the infection is in the body and how serious the infection is. A solution for bolus injection is prepared by dissolving the drug product meropenem in sterile water for injection to a final concentration of 50 mg/ml. The solution should be shaken before use. 4.7 Effects on ability to drive and use machines. Start typing to retrieve search suggestions. There are no established dose recommendations for patients receiving peritoneal dialysis. If you get any side effects, talk to your doctor or nurse. It is recommended that the INR should be monitored frequently during and shortly after coadministration of antibiotics with an oral anti-coagulant agent. This may be associated with a high fever and joint. Meropenem is indicated for the treatment of the following infections in adults and children aged 3 months and older (see sections 4.4 and 5.1): • Severe pneumonia, including hospital and ventilator-associated pneumonia. Symptomatic treatments should be considered. The measured renal clearance and the effect of probenecid show that meropenem undergoes both filtration and tubular secretion. In this case, the prepared solution if stored under refrigeration (i.e. Until there is evidence regarding clinical response for confirmed isolates with MIC values above the current resistant breakpoint they should be reported resistant. A study of 12 patients administered meropenem 1000 mg 8 hourly post-surgically for intra-abdominal infections showed a comparable Cmax and half-life to normal subjects but a greater volume of distribution 27 l. The average plasma protein binding of meropenem was approximately 2 % and was independent of concentration. Ceftriaxone Injection IP. The recommended dose regimens are shown in the table below: There is no experience in children with renal impairment. From a microbiological point of view, unless the method of opening/reconstitution/dilution precludes the risk of microbiological contamination, the product should be used immediately. Product after reconstitution is clear colourless to yellow solution. These include reduced numbers of platelets (which may make you bruise more easily), increased numbers of some white blood cells, decreased numbers of other white cells and increased amounts of a substance called ‘bilirubin’. Netherlands : AstraZeneca BV . No dose adjustment is necessary in patients with hepatic impairment (see section 4.4). Any of these side effects could affect your ability to drive or operate machines. 24*7 network in all area of gujarat. No dose adjustment is required for the elderly with normal renal function or creatinine clearance values above 50 ml/min. This medicinal product must not be mixed with other medicinal products except those mentioned in section 6.6. Medicinal products that inhibit peristalsis should not be given. Meropenem has been shown to penetrate well into several body fluids and tissues: including lung, bronchial secretions, bile, cerebrospinal fluid, gynaecological tissues, skin, fascia, muscle, and peritoneal exudates. What Meropenem is and what it is used for, What you need to know before you take Meropenem, Contents of the pack and other information. Before initiating therapy with meropenem, careful inquiry should be made concerning previous hypersensitivity reactions to beta-lactam antibiotics. Chemical and physical in-use stability for a prepared solution for infusion using 0.9% sodium chloride solution has been demonstrated for 6 hours at controlled room temperature (15-25°C) or upto12 hours under refrigerated conditions (2-8°C). Only clear colourless to yellow solution, free from particles should be used. The dose for children over 3 months old and up to 12 years of age is decided using the age and weight of the child. Haemodialysis will remove meropenem and its metabolite. You should check with your doctor if you are not, Your injection should not be mixed with or added to solutions that contain other, The injection may take about 5 minutes or between 15 and 30 minutes. The prevalence of acquired resistance may vary geographically and with time for selected species and local information on resistance is desirable, particularly when treating severe infections. 5 Non-species related breakpoints have been determined mainly from PK/PD data and are independent of the MIC distributions of specific species. Treatment of patients with bacteraemia that occurs in association with, or is suspected to be associated with, any of the infections listed above. No dose adjustment is necessary in patients with hepatic impairment (see section 4.4). It may harm them, even if their signs of illness are the same as yours. Each vial contains meropenem trihydrate equivalent to 500 mg anhydrous meropenem. Isolates may be reported as R without prior testing. • If you have any … If you get any side effects, talk to your doctor or nurse. Meropenem may be used in the management of neutropenic patients with fever that is suspected to be due to a bacterial infection. Your doctor or nurse will normally give Meropenem to, However, some patients, parents and carers are trained to give Meropenem at home. There have been many reports of increases in the anti-coagulant effects of orally administered anti-coagulant agents, including warfarin in patients who are concomitantly receiving antibacterial agents. Intravenous powder for solution: 500 mg/vial and 1 gram/vial. There are no or limited amount of data from the use of meropenem in pregnant women. Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. There is no dose adjustment necessary (see section 4.2). Relative overdose may be possible in patients with renal impairment if the dose is not adjusted as described in section 4.2. Meropenem concentrations in the CSF of children with meningitis are approximately 20 % of concurrent plasma levels although there is significant inter- individual variability. European Committee on Antimicrobial Susceptibility Testing (EUCAST) clinical breakpoints for MIC testing are presented below. Limited human data suggests that the drug does not represent any significant risk to the baby. Tutkimuksia Meropenem Hospiran vaikutuksesta ajokykyyn tai kykyyn käyttää koneita ei ole tehty. Meropenem concentrations in the CSF of children with meningitis are approximately 20 % of concurrent plasma levels although there is significant inter- individual variability. Merokem 1 gm Injection should be used with caution in patients with kidney disease. Changes in blood tests, including tests that show how well your kidneys are working. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive. You may need urgent medical treatment. Product after reconstitution is clear colourless to yellow solution. The hospital staff make it up into a solution before injection. Meropenem Injection IP stockiest and super stockiest (distributor) in the field of tablets, syrup, otc, antibiotics, life saving and critical care products. If a severe allergic reaction occurs, the medicinal product should be discontinued and appropriate measures taken. Limited post-marketing experience indicates that if adverse reactions occur following overdose, they are consistent with the adverse reaction profile described in section 4.8, are generally mild in severity and resolve on withdrawal or dose reduction. Some people may develop side effects like nausea, vomiting, diarrhea, rash or local redness and swelling at the site of injection. Consideration should be given to official guidance on the appropriate use of antibacterial agents. Chemical and physical in-use stability for a prepared solution for infusion using 0.9% sodium chloride solution has been demonstrated for 6 hours at controlled room temperature (15-25°C) or upto12 hours under refrigerated conditions (2-8°C). Pharmacokinetic studies in healthy elderly subjects (65-80 years) have shown a reduction in plasma clearance, which correlated with age-associated reduction in creatinine clearance, and a smaller reduction in non-renal clearance.
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